The first game on the 2025 NFL schedule finds the defending Super Bowl champion Philadelphia Eagles playing host to their NFC East rivals, the Dallas Cowboys. That game takes place on Thursday, September 4, from Lincoln Financial Field in Philly. The Eagles are the distinct betting favorites.
The Eagles and Cowboys have met 132 times over the years. Dallas holds the advantage over Philadelphia with an all-time record of 74-58. The teams played twice during the 2024 NFL season, the Eagles won both of those games, beating the Cowboys in Dallas in November (34-6) and at home in Philly in late December (41-7). The last time Philadelphia beat Dallas in three consecutive games came in 2003-04.
Before we lay out the odds, preview, and prediction for the Dallas Cowboys vs. Philadelphia Eagles in Week 1 2025 NFL action, check out our NFL betting odds and Super Bowl LX odds for 2026.
| NFL Week 1 |  |  |  |
|---|---|---|---|
| Dallas Cowboys | +237 | +250 | +240 |
| Philadelphia Eagles | -290 | -300 | -290 |
| Dallas Cowboys +7 | -112 | -105 | -110 |
| Philadelphia Eagles -7 | -108 | -115 | +110 |
| Over 46.0 | -110 | -120 | -110 |
| Under 46.0 | -110 | EVEN | +110 |
The Dallas Cowboys’ run of making the playoffs for three consecutive seasons ended last year, when the club finished with a losing record for the first time since 2020, when they went 6-10. The Cowboys wrapped up 2024 with a 7-10 record. That span, 2020-24, was the entire run of Mike McCarthy’shead coaching tenure in Dallas. The Cowboys replaced McCarthy with Brian Schottenheimer, who is moving into his first head coaching gig.
Expect some growing pains this year in Dallas. As the team gets accustomed to its new coach and his schemes.
The team lost future Hall of Fame guard Zack Martin to retirement and defensive end Demarcus Lawrence to Seattle in free agency. Those two are likely to be replaced by players the team drafted this year, guard Tyler Booker and defensive end Donovan Ezeiruaku.
The team is also without defensive star Micah Parsons, who is waiting on a contract extension from the front office. The Cowboys’ defense cannot afford to be without Parsons to start the season.
There is some good news: quarterback Dak Prescott, who played only eight games in 2024, is back and healthy.
The Philadelphia Eagles enter the 2025 NFL season as the defending Super Bowl champs, beating the Kansas City Chiefs 40-22 in Super Bowl LIX. After a 14-3 run during the regular season. As is often the case, some expect the team to suffer a Super Bowl hangover in the early part of the year, which they cannot afford, as they open the season with games against Dallas and Kansas City.
The Eagles offense is pretty much the same as last year, being led by quarterback Jalen Hurts, running back Saquon Barkley, and receivers A.J. Brown and DeVonta Smith. However, the team does have a new offensive coordinator. Kevin Patullo has replaced Kellen Moore, who is now head coach of the New Orleans Saints.
The defense is where to watch the Eagles as they lost some key players in the off season in edge rushers Brandon Graham and Josh Sweat, cornerback Darius Slay, safety C.J. Gardner-Johnson and defensive tackle Milton Williams.
The Eagles have most of their Super Bowl winning team returning this year, and after that club handled last year’s Cowboys with ease, expect the same type of game after Philadelphia raises the Super Bowl LIX championship banner before the game.
The betting pick is for the Philadelphia Eagles to beat the Dallas Cowboys in Week 1 NFL action.
The Eagles did not have any difficulty running up the score against the Cowboys in 2024, with that in mind, look for Philadelphia to cover the spread.
The betting pick is that the Philadelphia Eagles will cover the spread against the Dallas Cowboys in Week 1 NFL action.
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