Week 6 of the 2025 NFL season features an important matchup between the Detroit Lions and the Kansas City Chiefs. The game takes place at GEHA Field at Arrowhead Stadium in Kansas City, and it is the late game on the NFL schedule for Sunday, October 12.
The Lions are the top team in the NFC North, boasting a 4-1 record on the year. Detroit opened the year with a 27-13 loss to the Green Bay Packers. The club is unbeaten since then, earning wins over the Chicago Bears, Baltimore Ravens, Cleveland Browns, and Cincinnati Bengals. Meanwhile, the Chiefs are third in the AFC West with a record of 2-3. Kansas City opened the season 0-2, but bounced back with wins in its next two outings, including a win over the Ravens. However, the club found itself on the wrong end of a 31-28 game against the Jacksonville Jaguars last week.
The Lions and Chiefs have faced off 15 times. Kansas City holds the series lead at 9-6. The most recent meeting between the teams took place in 2023, when the Lions won 21-20.
Before we lay out the odds, preview, and prediction for the Detroit Lions vs. Kansas City Chiefs in Week 6 2025 NFL action, check out our NFL betting odds and Super Bowl LX odds for 2026.
| Teams |  |  |  |
|---|---|---|---|
| Detroit Lions | +117 | +120 | +120 |
| Kansas City Chiefs | -137 | -140 | -140 |
| Detroit Lions +2.5 | -108 | -110 | -105 |
| Kansas City Chiefs -2.5 | -112 | -110 | -115 |
| Over 53 Points | -110 | -110 | -110 |
| Under 53 Points | -110 | -110 | -110 |
The Detroit Lions enter Week 6 of the 2025 NFL season with the No. 1 scoring offense in the league with an average of 34.8 points per game. Meanwhile, the defense ranks 17th, allowing 22.4 points per game.
Quarterback Jared Goff is 10th in the NFL in yards (1,187), completions (109), and yards per game (237.4). Goff is seventh in average(8.2 yards). He leads the league in completion percentage at 75.2. He has an NFL-leading 12 touchdown passes and has thrown two interceptions on the year, while being sacked eight times.
In addition to Goff’s passing, look for Detroit to get the ball to running back Jahmyr Gibbs often. Gibbs is 12th in the NFL in yards and averaging 4.6 yards per carry. The Chiefs’ defense has surrendered an average of 4.8 yards per carry this season.
On defense, look for the Lions to use their pass rush to pressure Kansas City early and often. The Chiefs do not have the type of running game that will stop the Lions from rushing Patrick Mahomes. The Lions have the No. 10 passing defense in the NFL. The team ranks seventh in rushing defense.
With four wins in a row, the Lions might be the hottest team in the NFL right now, and the team should feel confident heading into Kansas City to face a team that has not played up to expectations so far this season.
This year marked the first time the Kansas City Chiefs opened the season at 0-2 with Patrick Mahomes at quarterback. While the team managed a win in Week 3, they carry a losing record with them into Week 6 of the 2025 NFL season.
The Chiefs will have home-field advantage in this game, but given the team’s current performance and the momentum the surging Lions bring into Arrowhead Stadium, I wouldn’t put too much stock in that supposed advantage.
The Kansas City offense ranks 25th in the NFL in points per game (25), while the defense is 13th in that category (21.4).
Mahomes is sixth in the NFL in yards (1,257) and yards per game (251.4), and fifth in completions (116). The KC QB ranks 22nd in average (6.9) and 25th in completion percentage (63.4). Mahomes has thrown eight touchdowns and two interceptions. He’s been sacked nine times.
The Chiefs were looking for Isiah Pacheco to be a force at running back this season. He has not been. Pacheco is third on the team in yards (163), behind Kareem Hunt (164) and Mahomes (190) in rushing. The lack of a rushing game makes defensive decisions very easy for the Chiefs’ opposition.
The Chiefs are 0-3 against tough opposition and have the same record in one-score games this season. And if you’re looking for field goals to save this club, Harrison Butker has missed five kicks this year.
The Lions are currently the best team in the NFL. Meanwhile, you’d be hard-pressed to find anyone who sees the Chiefs as an elite club heading into Week 6. This is an enormous game for Kansas City, but they are not playing well, and the pick is for Detroit to pull off the upset.
The betting pick is that the Detroit Lions will beat the Kansas City Chiefs in Week 6 NFL action.
Take the points on the Lions in Week 6.
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